TY - JOUR
T1 - Hypertension and brain catecholamine distribution in the Hebrew University Sabra, H and N rats.
AU - Zamir, N.
AU - Gutman, Y.
AU - Ben-Ishay, D.
PY - 1978/12
Y1 - 1978/12
N2 - 1. The concentration of catecholamines was measured in several brain areas of the Hewbrew University Sabra rat (SB rat), and in two substrains selected for their respective sensitivity (H) or immunity (N) to hypertension. 2. Hypertension was induced in SB rats by DOCA-salt, renal artery constriction and NaCl 1.7% drinking. The noradrenaline content was consistently elevated in the medulla oblongata of hypertension animals. In other brain areas the rise in noradrenaline varied in the different types of hypertension. 3. Administration of DOCA-salt to H and N rats, while causing marked hypertension in the former, had no effect on noradrenaline in either strain. 4. Untreated, normotensive N rats had in the medulla oblongata, significantly higher concentrations of noradrenaline than did H rats. 5. Differences in brain noradrenaline may explain the inherited susceptibility or resistance to hypertension in H and N rats.
AB - 1. The concentration of catecholamines was measured in several brain areas of the Hewbrew University Sabra rat (SB rat), and in two substrains selected for their respective sensitivity (H) or immunity (N) to hypertension. 2. Hypertension was induced in SB rats by DOCA-salt, renal artery constriction and NaCl 1.7% drinking. The noradrenaline content was consistently elevated in the medulla oblongata of hypertension animals. In other brain areas the rise in noradrenaline varied in the different types of hypertension. 3. Administration of DOCA-salt to H and N rats, while causing marked hypertension in the former, had no effect on noradrenaline in either strain. 4. Untreated, normotensive N rats had in the medulla oblongata, significantly higher concentrations of noradrenaline than did H rats. 5. Differences in brain noradrenaline may explain the inherited susceptibility or resistance to hypertension in H and N rats.
UR - http://www.scopus.com/inward/record.url?scp=0018162181&partnerID=8YFLogxK
U2 - 10.1042/cs055105s
DO - 10.1042/cs055105s
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C2 - 282036
AN - SCOPUS:0018162181
SN - 0144-4107
VL - 4
SP - 105s-107s
JO - Clinical science and molecular medicine. Supplement
JF - Clinical science and molecular medicine. Supplement
ER -