Hypolipidemia induced by PPARα agonists: HNF-4α as an alternative to PPARα

Jacob Bar-Tana*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

This critical review examines the putative role played by peroxisome proliferator-activated receptor alpha (PPARα) in the hypolipidemic activity induced by peroxisome proliferators/PPARα agonists. The hypolipidemic effect of peroxisome proliferators mediated in rodents by hepatic PPARα activation is independent of PPARα in humans, and is transduced by direct suppression of hepatocyte nuclear factor-4alpha by the CoA-thioesters of hypolipidemic peroxisome proliferators. A novel target for hypolipidemic drugs in humans and an updated risk assessment for human hypolipidemic drugs are implied.

Original languageEnglish
Pages (from-to)941-946
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Volume5
Issue number9
StatePublished - Sep 2004

Keywords

  • HNF-4αhypolipidemia, PPARα

Fingerprint

Dive into the research topics of 'Hypolipidemia induced by PPARα agonists: HNF-4α as an alternative to PPARα'. Together they form a unique fingerprint.

Cite this