Abstract
This critical review examines the putative role played by peroxisome proliferator-activated receptor alpha (PPARα) in the hypolipidemic activity induced by peroxisome proliferators/PPARα agonists. The hypolipidemic effect of peroxisome proliferators mediated in rodents by hepatic PPARα activation is independent of PPARα in humans, and is transduced by direct suppression of hepatocyte nuclear factor-4alpha by the CoA-thioesters of hypolipidemic peroxisome proliferators. A novel target for hypolipidemic drugs in humans and an updated risk assessment for human hypolipidemic drugs are implied.
Original language | English |
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Pages (from-to) | 941-946 |
Number of pages | 6 |
Journal | Current Opinion in Investigational Drugs |
Volume | 5 |
Issue number | 9 |
State | Published - Sep 2004 |
Keywords
- HNF-4αhypolipidemia, PPARα