Ice-Binding Proteins and Their Function

Maya Bar Dolev, Ido Braslavsky, Peter L. Davies

Research output: Contribution to journalArticlepeer-review

263 Scopus citations


Ice-binding proteins (IBPs) are a diverse class of proteins that assist organism survival in the presence of ice in cold climates. They have different origins in many organisms, including bacteria, fungi, algae, diatoms, plants, insects, and fish. This review covers the gamut of IBP structures and functions and the common features they use to bind ice. We discuss mechanisms by which IBPs adsorb to ice and interfere with its growth, evidence for their irreversible association with ice, and methods for enhancing the activity of IBPs. The applications of IBPs in the food industry, in cryopreservation, and in other technologies are vast, and we chart out some possibilities.

Original languageAmerican English
Pages (from-to)515-542
Number of pages28
JournalAnnual Review of Biochemistry
StatePublished - 2 Jun 2016

Bibliographical note

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© Copyright 2016 by Annual Reviews. All rights reserved.


  • Anchored clathrate waters
  • Antifreeze proteins
  • Ice-binding site
  • Ice-structuring proteins
  • Thermal hysteresis


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