Identification and nucleotide sequence of Brucella melitensis L7/L12 ribosomal protein

Gilad Bachrach, Dror Bar-Nir, Menachem Banai, Herve Bercovier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

DNA sequencing of the gene encoding a Brucella melitensis 12-kDa protein revealed that this protein was the ribosomal protein L7/L12. The B. melitensis L7/L12 DNA sequence was identical to that of the corresponding B. abortus gene, showing the near identity of these two organisms. When comparing the sequence of this protein to that of other organisms some domains were highly conserved, especially the C-terminus, which contrasted with the lack of conservation of the sequences at the N-terminus. The finding that the ribosomal protein L7/L12 of Brucella is an immunodominant antigen provides a new rationale to explain the activity of ribosomal vaccines.

Original languageAmerican English
Pages (from-to)237-240
Number of pages4
JournalFEMS Microbiology Letters
Volume120
Issue number3
DOIs
StatePublished - 15 Jul 1994

Bibliographical note

Funding Information:
This research was supported in part by funds provided by the Agency for International Development under the Middle East regional cooperation program, managed by the US Department of Agriculture, Trinational animal health program and by grant IS-1434-88 from the US-Israel BARD foundation.

Keywords

  • Brucella melitensis
  • DNA sequence
  • L7/L12
  • Ribosomal protein

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