Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding

Keyphrases

• Wild-type p53 100%
• Transforming Activity 100%
• Abrogation 100%
• Miniprotein 100%
• Sequence-specific DNA Binding 100%
• Negative Dominance 100%
• In Cancer 50%
• Oligomerization 50%
• DNA Binding 50%
• In Vitro Activity 50%
• Dominant Negative 50%
• Point mutation 50%
• Mutant p53 50%
• Mutant Protein 50%
• P53 Gene 50%
• P53 mutant 50%
• Endogenous Cells 50%
• Incompetence 50%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• DNA Binding 100%
• Wild Type 25%
• C-Terminus 12%
• Oligomerization 12%
• Point Mutation 12%
• Protein P53 12%
• Mutant Protein 12%

Immunology and Microbiology

• P53 100%
• DNA Binding 100%
• Wild Type 22%
• Point Mutation 11%
• Carboxy Terminal Sequence 11%
• Transformed Cell 11%
• Oligomerization 11%