Identification of early postmitotic cells in distinct embryonic sites and their possible roles in morphogenesis

Nitza Kahane, Chaya Kalcheim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Differential proliferation within defined embryonic anlage is likely to play a major role in morphogenesis. We have identified cell populations in the avian embryo that begin exiting the cell cycle as early as the 25-somite stage. These include first the floor plate and then the roof plate of the neural tube, cells that constitute the lamina terminalis and the diencephalic-mesencephalic junction of the developing brain. Outside the nervous system, the central portion of the notochord contains early postmitotic cells. In the heart, such cells will populate the epimyocardium at the level of the truncus arteriosus exclusively and the endocardial cushions that serve as an anchor for the growing intracardial septa. Surprisingly, the endoderm at the level of the prospective midgut is composed of post-mitotic progenitors. These cells are later found both in the caudal portion of the duodenum and in derivatives adjacent to the umbilical region of the primitive midgut. The possible implications of this early, localized withdrawal from the cell cycle to morphogenetic events and lineage segregation are discussed.

Original languageAmerican English
Pages (from-to)297-307
Number of pages11
JournalCell and Tissue Research
Volume294
Issue number2
DOIs
StatePublished - 1998

Bibliographical note

Funding Information:
This work was supported by grants from the March of Dimes, the Israel Cancer Research Foundation, and the Dysautonomia Foundation to C.K.

Keywords

  • Coturnix coturnix japonical (Aves)
  • Endocardial cushion
  • Floor plate
  • Gut
  • Heart septation
  • Neural crest
  • Neural tube
  • Notochord

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