Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity

Mark R. Smith, Matthew G. Boenzli, Vihangi Hindagolla, Jun Ding, John M. Miller, James E. Hutchison, Jeffrey A. Greenwood, Hagai Abeliovich, Alan T. Bakalinsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

Original languageAmerican English
Pages (from-to)728-733
Number of pages6
JournalApplied and Environmental Microbiology
Volume79
Issue number2
DOIs
StatePublished - Jan 2013

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