Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity

Mark R. Smith; Matthew G. Boenzli; Vihangi Hindagolla; Jun Ding; John M. Miller; James E. Hutchison; Jeffrey A. Greenwood; Hagai Abeliovich; Alan T. Bakalinsky

doi:10.1128/AEM.01737-12

Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity

Mark R. Smith
, Matthew G. Boenzli
, Vihangi Hindagolla
, Jun Ding
, John M. Miller
, James E. Hutchison
, Jeffrey A. Greenwood
, Hagai Abeliovich
, Alan T. Bakalinsky^*

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

Original language	English
Pages (from-to)	728-733
Number of pages	6
Journal	Applied and Environmental Microbiology
Volume	79
Issue number	2
DOIs	https://doi.org/10.1128/AEM.01737-12
State	Published - Jan 2013

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Smith, M. R., Boenzli, M. G., Hindagolla, V., Ding, J., Miller, J. M., Hutchison, J. E., Greenwood, J. A., Abeliovich, H., & Bakalinsky, A. T. (2013). Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity. Applied and Environmental Microbiology, 79(2), 728-733. https://doi.org/10.1128/AEM.01737-12

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abstract = "Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.",

author = "Smith, \{Mark R.\} and Boenzli, \{Matthew G.\} and Vihangi Hindagolla and Jun Ding and Miller, \{John M.\} and Hutchison, \{James E.\} and Greenwood, \{Jeffrey A.\} and Hagai Abeliovich and Bakalinsky, \{Alan T.\}",

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Smith, MR, Boenzli, MG, Hindagolla, V, Ding, J, Miller, JM, Hutchison, JE, Greenwood, JA, Abeliovich, H & Bakalinsky, AT 2013, 'Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity', Applied and Environmental Microbiology, vol. 79, no. 2, pp. 728-733. https://doi.org/10.1128/AEM.01737-12

TY - JOUR

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AU - Smith, Mark R.

AU - Boenzli, Matthew G.

AU - Hindagolla, Vihangi

AU - Ding, Jun

AU - Miller, John M.

AU - Hutchison, James E.

AU - Greenwood, Jeffrey A.

AU - Abeliovich, Hagai

AU - Bakalinsky, Alan T.

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AB - Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

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Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity

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