Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan; Nicholas Craddock; Nadine Norton; Hywel Williams; Timothy Peirce; Valentina Moskvina; Ivan Nikolov; Marian Hamshere; Liam Carroll; Lyudmila Georgieva; Sarah Dwyer; Peter Holmans; Jonathan L. Marchini; Chris C.A. Spencer; Bryan Howie; Hin Tak Leung; Annette M. Hartmann; Hans Jürgen Möller; Derek W. Morris; Yong Yong Shi; Guo Yin Feng; Per Hoffmann; Peter Propping; Catalina Vasilescu; Wolfgang Maier; Marcella Rietschel; Stanley Zammit; Johannes Schumacher; Emma M. Quinn; Thomas G. Schulze; Nigel M. Williams; Ina Giegling; Nakao Iwata; Masashi Ikeda; Ariel Darvasi; Sagiv Shifman; Lin He; Jubao Duan; Alan R. Sanders; Douglas F. Levinson; Pablo V. Gejman; Nancy G. Buccola; Bryan J. Mowry; Robert Freedman; Farooq Amin; Donald W. Black; Jeremy M. Silverman; William F. Byerley; C. Robert Cloninger; Sven Cichon; Markus M. Nöthen; Michael Gill; Aiden Corvin; Dan Rujescu; George Kirov; Michael J. Owen

doi:10.1038/ng.201

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L. Marchini, Chris C.A. Spencer, Bryan Howie, Hin Tak Leung, Annette M. Hartmann, Hans Jürgen Möller, Derek W. Morris, Yong Yong ShiGuo Yin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M. Quinn, Thomas G. Schulze, Nigel M. Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R. Sanders, Douglas F. Levinson, Pablo V. Gejman, Nancy G. Buccola, Bryan J. Mowry, Robert Freedman, Farooq Amin, Donald W. Black, Jeremy M. Silverman, William F. Byerley, C. Robert Cloninger, Sven Cichon, Markus M. Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael J. Owen

Department of Genetics

Research output: Contribution to journal › Article › peer-review

940 Scopus citations

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10^-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10^-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10^-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10^-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10^-9).

Original language	English
Pages (from-to)	1053-1055
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	9
DOIs	https://doi.org/10.1038/ng.201
State	Published - Sep 2008

Bibliographical note

Funding Information:
The UK research was supported by grants from the MRC and the Wellcome Trust. We are grateful to the Wellcome Trust Case Control Consortium for access to control genotypes (and to the individuals acknowledged in that respect in ref. 4) and their contribution to the genome-wide study, and to the Welsh e-Science Centre at Cardiff University for access to computing resources for some of this work. In Dublin, the research was supported by Science Foundation Ireland, the Health Research Board (Ireland) and the Wellcome Trust. We are grateful to J. Waddington for sample recruitment. Irish controls were supplied by J. McPartlin and the Trinity College Biobank. In Bonn and Mannheim, the work was supported by the National Genomic Network of the ‘Bundesministerium für Bildung und Forschung’ (BMBF) and the Alfried Krupp von Bohlen und Halbach-Stiftung. We also thank the Department of Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples. Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the Hebrew University Genetic Resource.

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O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H. T., Hartmann, A. M., Möller, H. J., Morris, D. W., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201

@article{11f170d2851542bdb01a15e77ec68a2f,

title = "Identification of loci associated with schizophrenia by genome-wide association and follow-up",

abstract = "We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).",

author = "O'Donovan, {Michael C.} and Nicholas Craddock and Nadine Norton and Hywel Williams and Timothy Peirce and Valentina Moskvina and Ivan Nikolov and Marian Hamshere and Liam Carroll and Lyudmila Georgieva and Sarah Dwyer and Peter Holmans and Marchini, {Jonathan L.} and Spencer, {Chris C.A.} and Bryan Howie and Leung, {Hin Tak} and Hartmann, {Annette M.} and M{\"o}ller, {Hans J{\"u}rgen} and Morris, {Derek W.} and Shi, {Yong Yong} and Feng, {Guo Yin} and Per Hoffmann and Peter Propping and Catalina Vasilescu and Wolfgang Maier and Marcella Rietschel and Stanley Zammit and Johannes Schumacher and Quinn, {Emma M.} and Schulze, {Thomas G.} and Williams, {Nigel M.} and Ina Giegling and Nakao Iwata and Masashi Ikeda and Ariel Darvasi and Sagiv Shifman and Lin He and Jubao Duan and Sanders, {Alan R.} and Levinson, {Douglas F.} and Gejman, {Pablo V.} and Buccola, {Nancy G.} and Mowry, {Bryan J.} and Robert Freedman and Farooq Amin and Black, {Donald W.} and Silverman, {Jeremy M.} and Byerley, {William F.} and Cloninger, {C. Robert} and Sven Cichon and N{\"o}then, {Markus M.} and Michael Gill and Aiden Corvin and Dan Rujescu and George Kirov and Owen, {Michael J.}",

note = "Funding Information: The UK research was supported by grants from the MRC and the Wellcome Trust. We are grateful to the Wellcome Trust Case Control Consortium for access to control genotypes (and to the individuals acknowledged in that respect in ref. 4) and their contribution to the genome-wide study, and to the Welsh e-Science Centre at Cardiff University for access to computing resources for some of this work. In Dublin, the research was supported by Science Foundation Ireland, the Health Research Board (Ireland) and the Wellcome Trust. We are grateful to J. Waddington for sample recruitment. Irish controls were supplied by J. McPartlin and the Trinity College Biobank. In Bonn and Mannheim, the work was supported by the National Genomic Network of the {\textquoteleft}Bundesministerium f{\"u}r Bildung und Forschung{\textquoteright} (BMBF) and the Alfried Krupp von Bohlen und Halbach-Stiftung. We also thank the Department of Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples. Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the Hebrew University Genetic Resource.",

year = "2008",

month = sep,

doi = "10.1038/ng.201",

language = "אנגלית",

volume = "40",

pages = "1053--1055",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "9",

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O'Donovan, MC, Craddock, N, Norton, N, Williams, H, Peirce, T, Moskvina, V, Nikolov, I, Hamshere, M, Carroll, L, Georgieva, L, Dwyer, S, Holmans, P, Marchini, JL, Spencer, CCA, Howie, B, Leung, HT, Hartmann, AM, Möller, HJ, Morris, DW, Shi, YY, Feng, GY, Hoffmann, P, Propping, P, Vasilescu, C, Maier, W, Rietschel, M, Zammit, S, Schumacher, J, Quinn, EM, Schulze, TG, Williams, NM, Giegling, I, Iwata, N, Ikeda, M, Darvasi, A, Shifman, S, He, L, Duan, J, Sanders, AR, Levinson, DF, Gejman, PV, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Cloninger, CR, Cichon, S, Nöthen, MM, Gill, M, Corvin, A, Rujescu, D, Kirov, G & Owen, MJ 2008, 'Identification of loci associated with schizophrenia by genome-wide association and follow-up', Nature Genetics, vol. 40, no. 9, pp. 1053-1055. https://doi.org/10.1038/ng.201

TY - JOUR

T1 - Identification of loci associated with schizophrenia by genome-wide association and follow-up

AU - O'Donovan, Michael C.

AU - Craddock, Nicholas

AU - Norton, Nadine

AU - Williams, Hywel

AU - Peirce, Timothy

AU - Moskvina, Valentina

AU - Nikolov, Ivan

AU - Hamshere, Marian

AU - Carroll, Liam

AU - Georgieva, Lyudmila

AU - Dwyer, Sarah

AU - Holmans, Peter

AU - Marchini, Jonathan L.

AU - Spencer, Chris C.A.

AU - Howie, Bryan

AU - Leung, Hin Tak

AU - Hartmann, Annette M.

AU - Möller, Hans Jürgen

AU - Morris, Derek W.

AU - Shi, Yong Yong

AU - Feng, Guo Yin

AU - Hoffmann, Per

AU - Propping, Peter

AU - Vasilescu, Catalina

AU - Maier, Wolfgang

AU - Rietschel, Marcella

AU - Zammit, Stanley

AU - Schumacher, Johannes

AU - Quinn, Emma M.

AU - Schulze, Thomas G.

AU - Williams, Nigel M.

AU - Giegling, Ina

AU - Iwata, Nakao

AU - Ikeda, Masashi

AU - Darvasi, Ariel

AU - Shifman, Sagiv

AU - He, Lin

AU - Duan, Jubao

AU - Sanders, Alan R.

AU - Levinson, Douglas F.

AU - Gejman, Pablo V.

AU - Buccola, Nancy G.

AU - Mowry, Bryan J.

AU - Freedman, Robert

AU - Amin, Farooq

AU - Black, Donald W.

AU - Silverman, Jeremy M.

AU - Byerley, William F.

AU - Cloninger, C. Robert

AU - Cichon, Sven

AU - Nöthen, Markus M.

AU - Gill, Michael

AU - Corvin, Aiden

AU - Rujescu, Dan

AU - Kirov, George

AU - Owen, Michael J.

N1 - Funding Information: The UK research was supported by grants from the MRC and the Wellcome Trust. We are grateful to the Wellcome Trust Case Control Consortium for access to control genotypes (and to the individuals acknowledged in that respect in ref. 4) and their contribution to the genome-wide study, and to the Welsh e-Science Centre at Cardiff University for access to computing resources for some of this work. In Dublin, the research was supported by Science Foundation Ireland, the Health Research Board (Ireland) and the Wellcome Trust. We are grateful to J. Waddington for sample recruitment. Irish controls were supplied by J. McPartlin and the Trinity College Biobank. In Bonn and Mannheim, the work was supported by the National Genomic Network of the ‘Bundesministerium für Bildung und Forschung’ (BMBF) and the Alfried Krupp von Bohlen und Halbach-Stiftung. We also thank the Department of Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples. Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the Hebrew University Genetic Resource.

PY - 2008/9

Y1 - 2008/9

N2 - We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).

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SP - 1053

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JF - Nature Genetics

IS - 9

ER -

Identification of loci associated with schizophrenia by genome-wide association and follow-up

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Bibliographical note

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