Identification of the eight-membered heterocycles hicksoanes A-C from the gorgonian Subergorgia hicksoni

Tomáš Řezanka*, Lumír O. Hanuš, Valery M. Dembitsky, Karel Sigler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Novel eight-membered heterocycles, named hicksoanes A-C, were isolated from the gorgonian Subergorgia hicksoni. Their structures, including the absolute configuration of all three stereocenters, were determined by means of extensive spectroscopic data. Hicksoanes have a unique structure containing a triazocane cycle, which is substituted by isoleucine and tryptophan moieties. Hicksoanes A-C showed antifeeding activity against goldfish at natural concentration (≈10 μg mL-1).

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number7
DOIs
StatePublished - Mar 2008

Keywords

  • Gorgonians
  • Hicksoanes A-C
  • Natural products
  • Nitrogen heterocycles

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