Identifying novel constrained elements by exploiting biased substitution patterns

Keyphrases

• Rate-based 100%
• Substitution Pattern 100%
• Conserved Sequence 50%
• Statistical Methods 50%
• Closely Related Species 50%
• Sequence Alignment 50%
• Learning Algorithm 50%
• Natural Selection 50%
• Hidden Markov Model 50%
• Across Species 50%
• Nucleotide Substitution 50%
• Pattern Characteristic 50%
• Reference Genome 50%
• Functional Elements 50%
• Evolutionary Selection 50%
• Site-specific Substitution 50%
• Constrained Sequences 50%
• Substitution Bias 50%

Biochemistry, Genetics and Molecular Biology

• Conserved Sequence 100%
• Sequence Alignment 100%
• Hidden Markov Model 100%
• Cladistics 100%
• Natural Selection 100%

Economics, Econometrics and Finance

• Hidden Markov Model 100%