IFN-γ treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner

Ido D. Weiss, Ori Wald, Hanna Wald, Katia Beider, Michal Abraham, Eithan Galun, Arnon Nagler, Amnon Peled*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Influenza pandemics are imminent and represent a major world health concern. Since vaccinations are expected to be less efficient in the coming years due to newly emerging influenza virus strains, novel antiviral therapies are urgently needed. Here, we show that influenza-infected mice, capable of clearing the virus in the early stages of infection, failed to control inflammation and death. Sequential administration of Interferon-γ (IFN-γ) at early stage of the infection protected infected mice from death in a NK cell-dependent manner. IFN-γ treatment stimulated NK cell proliferation and function and increased their number in the bone marrow, blood, spleen, and infected lungs, keeping viral clearance intact. In parallel, IFN-γ treatment significantly reduced the number of T cells and NKT cells in the lungs at the inflammatory phase following infection. Thus, rapidly clearing the virus and reducing inflammation by shaping the cellular and cytokine profiles in the early stages of infection may favorably change the fate of influenza pathogenesis.

Original languageAmerican English
Pages (from-to)439-449
Number of pages11
JournalJournal of Interferon and Cytokine Research
Volume30
Issue number6
DOIs
StatePublished - 1 Jun 2010
Externally publishedYes

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