TY - JOUR
T1 - IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
AU - Ben-Sasson, Shlomo Z.
AU - Hu-Li, Jane
AU - Quiel, Juan
AU - Cauchetaux, Stephane
AU - Ratner, Maya
AU - Shapira, Ilana
AU - Dinarello, Charles A.
AU - Paul, William E.
PY - 2009/4/28
Y1 - 2009/4/28
N2 - IL-1 causes a marked increase in the degree of expansion of naive and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1/β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1 -/- recipients, IL-1 increases the proportion of cytokine-pro-ducing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum lgG1 levels. IL-1β enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1 -/- recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by ≈55%. These results indicate that IL-1β signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.
AB - IL-1 causes a marked increase in the degree of expansion of naive and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1/β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1 -/- recipients, IL-1 increases the proportion of cytokine-pro-ducing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum lgG1 levels. IL-1β enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1 -/- recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by ≈55%. These results indicate that IL-1β signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.
KW - Cytokines
KW - Inflammasome
KW - Th1
KW - Th17
KW - Th2
UR - http://www.scopus.com/inward/record.url?scp=66349089266&partnerID=8YFLogxK
U2 - 10.1073/pnas.0902745106
DO - 10.1073/pnas.0902745106
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 19359475
AN - SCOPUS:66349089266
SN - 0027-8424
VL - 106
SP - 7119
EP - 7124
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 17
ER -