IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

Shlomo Z. Ben-Sasson, Jane Hu-Li, Juan Quiel, Stephane Cauchetaux, Maya Ratner, Ilana Shapira, Charles A. Dinarello, William E. Paul

Research output: Contribution to journalArticlepeer-review

467 Scopus citations

Abstract

IL-1 causes a marked increase in the degree of expansion of naive and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1/β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1 -/- recipients, IL-1 increases the proportion of cytokine-pro-ducing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum lgG1 levels. IL-1β enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1 -/- recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by ≈55%. These results indicate that IL-1β signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.

Original languageEnglish
Pages (from-to)7119-7124
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number17
DOIs
StatePublished - 28 Apr 2009

Keywords

  • Cytokines
  • Inflammasome
  • Th1
  • Th17
  • Th2

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