IL-1RI participates in normal growth plate development and bone modeling

Stav Simsa-Maziel, Janna Zaretsky, Adi Reich, Yoav Koren, Ron Shahar, Efrat Monsonego-Ornan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The proinflammatory cytokine interleukin-1 (IL-1) signals through IL-1 receptor type I (IL-1RI) and induces osteoclastogenesis and bone resorption mainly during pathological conditions. Little is known about the effect of excess or absence of IL-1 signaling on the physiological development of the growth plate and bone. In this study, we examine growth plate morphology, bone structure, and mechanical properties as well as osteoclast number in IL-1RI knockout mice to evaluate the role of IL-1RI in the normal development of the growth plate and bone. We show for the first time that IL-1RI knockout mice have narrower growth plates due to a smaller hypertrophic zone, suggesting a role for this cytokine in hypertrophic differentiation, together with higher proteoglycan content. The bones of theses mice exhibit higher trabecular and cortical mass, increased mineral density, and superior mechanical properties. In addition, IL-1RI knockout mice have significantly reduced osteoclast numbers in the chondro-osseous junction, trabecular bone, and cortical bone. These results suggest that IL-1RI is involved in normal growth plate development and ECM homeostasis and that it is significant in the physiological process of bone modeling.

Original languageAmerican English
Pages (from-to)E15-E21
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume305
Issue number1
DOIs
StatePublished - 1 Jul 2013

Keywords

  • Bone mechanics
  • Bone structure
  • Interleukin-1
  • Interleukin-1 receptor type I
  • Osteoclasts

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