Abstract
IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulatd spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 4224-4228 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 141 |
| Issue number | 12 |
| State | Published - 1988 |
| Externally published | Yes |
