IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors

M. Ogata, H. Lorberboum-Galski, D. Fitzgerald, I. Pastan

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulatd spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.

Original languageAmerican English
Pages (from-to)4224-4228
Number of pages5
JournalJournal of Immunology
Volume141
Issue number12
StatePublished - 1988
Externally publishedYes

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