IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors

M. Ogata; H. Lorberboum-Galski; D. Fitzgerald; I. Pastan

IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors

M. Ogata
, H. Lorberboum-Galski
, D. Fitzgerald
, I. Pastan

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulatd spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.

Original language	English
Pages (from-to)	4224-4228
Number of pages	5
Journal	Journal of Immunology
Volume	141
Issue number	12
State	Published - 1988
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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abstract = "IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulatd spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.",

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AU - Ogata, M.

AU - Lorberboum-Galski, H.

AU - Fitzgerald, D.

AU - Pastan, I.

PY - 1988

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AB - IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulatd spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.

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JF - Journal of Immunology

IS - 12

ER -

IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors

Abstract

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