Image-guided core-needle biopsy in malignant lymphoma: Experience with 100 patients that suggests the technique is reliable

D. Ben-Yehuda*, A. Polliack, E. Okon, Y. Sherman, S. Fields, P. Lebenshart, H. Lotan, E. Libson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


Purpose: In an initial evaluation of 1,500 computed tomography (CT)- guided core-needle biopsies performed at our institute during the period from 1989 to 1994, we encountered 100 patients with the diagnosis of lymphoma. Here, we review the clinical impact of 109 image-guided needle biopsies in these 100 patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). Patients and Methods: NHL was diagnosed in 71 patients, and 29 had HD. Among the NHL patients, 17 (24%) had proven lymphoma diagnosed before the biopsy was performed; in 54 (76%) core-needle biopsy was performed as the first diagnostic procedure. Of 29 HD patients, nine (31%) were already established cases of HD, and in 20 (69%) core-needle biopsy was the first diagnostic procedure attempted. Most of the biopsies were performed under CT control using a 20- or 18-gauge Turner biopsy needle. Results: Eighty-six patients received therapy based on the results of the needle biopsy alone. Fourteen patients received therapy after undergoing surgical biopsy for a suspected diagnosis of lymphoma, which could not be established with certainty on the basis of an earlier core-needle biopsy alone. In 78% of the patients, the needle biopsy saved a further surgical procedure that may have been difficult to perform because of the primary location of the tumor. Conclusion: From our experience in this study, image-guided core-needle biopsies provide sufficient information for the diagnosis of and subsequent therapeutic decision to treat most cases of lymphoma.

Original languageAmerican English
Pages (from-to)2431-2434
Number of pages4
JournalJournal of Clinical Oncology
Issue number9
StatePublished - 1996
Externally publishedYes


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