Image scanning lensless fiber-bundle endomicroscopy

Gil Weinberg, Weiss Uri Weiss, Ori Katz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Fiber-based confocal endomicroscopy has shown great promise for minimallyinvasive deep-Tissue imaging. Despite its advantages, confocal fiber-bundle endoscopy inherently suffers from undersampling due to the spacing between fiber cores, and low collection efficiency when the target is not in proximity to the distal fiber facet. Here, we demonstrate an adaptation of image-scanning microscopy (ISM) to lensless fiber bundle endoscopy, doubling the spatial sampling frequency and significantly improving collection efficiency. Our approach only requires replacing the confocal detector with a camera. It improves the spatial resolution for targets placed at a distance from the fiber tip, and addresses the fundamental challenge of aliasing/pixelization artifacts.

Original languageAmerican English
Pages (from-to)37050-37057
Number of pages8
JournalOptics Express
Volume31
Issue number22
DOIs
StatePublished - 23 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

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