Imaging the dynamics of mammalian neocortical population activity in-vivo

Amiram Grinvald*, David Omer, Shmuel Naaman, Dahlia Sharon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Neural computations underlying sensory perception, cognition and motor control are performed by populations of neurons at different anatomical and temporal scales. Few techniques are currently available for exploring dynamics of local and large range populations. Voltage-sensitive dye imaging (VSDI) reveals neural population activity in areas ranging from a few tens of microns to a couple of centimeters, or two areas up to ~10 cm apart. VSDI provides a sub-millisecond temporal resolution, and a spatial resolution of about 50 μm. The dye signal emphasizes subthreshold synaptic potentials. VSDI has been applied in the mouse, rat, gerbil, ferret, tree shrew, cat and monkey cortices, in order to explore lateral spread of retinotopic or somatotopic activation, the dynamic spatiotemporal pattern resulting from sensory activation, including the somatosensory, olfactory, auditory, and visual modalities, as well as motor preparation and the properties of spontaneously-occurring population activity. In this chapter we focus on VSDI in-vivo and review results obtained mostly in the visual system in our laboratory.

Original languageAmerican English
Pages (from-to)243-271
Number of pages29
JournalAdvances in Experimental Medicine and Biology
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2015.


  • Cat
  • Cortical response field
  • Evoked response
  • Horizontal connections
  • Lateral spread
  • Monkey
  • Orientation map
  • Orientation selectivity
  • Spatiotemporal response
  • Spikes
  • Spontaneous activity
  • Subthreshold response
  • V1
  • V2
  • Visual cortex


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