Imaging transporters: Transforming diagnostic and therapeutic development

A. Mann, H. Han, S. Eyal*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Molecular imaging allows noninvasive assessment of drug distribution across pharmacological barriers. Thus, it plays an increasingly important role in efforts to understand the interactions of molecules with membrane transporters during drug development and in clinical pharmacology. We describe established and emerging imaging modalities utilized for studying transporter expression and function. We further present examples of how molecular imaging could provide insights into the contribution of transporters to drug disposition and effects.

Original languageAmerican English
Pages (from-to)479-488
Number of pages10
JournalClinical Pharmacology and Therapeutics
DOIs
StatePublished - 1 Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 American Society for Clinical Pharmacology and Therapeutics

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