Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Hadar Cheriker; Tal Stern Bauer; Yuval Oren; Shlomo Nir; Zvi Hayouka

doi:10.1039/d0cc04759g

Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Hadar Cheriker, Tal Stern Bauer, Yuval Oren, Shlomo Nir, Zvi Hayouka^*

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.

Original language	English
Pages (from-to)	11022-11025
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	75
DOIs	https://doi.org/10.1039/d0cc04759g
State	Published - 25 Sep 2020

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© The Royal Society of Chemistry 2020.

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abstract = "In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.",

author = "Hadar Cheriker and {Stern Bauer}, Tal and Yuval Oren and Shlomo Nir and Zvi Hayouka",

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AU - Cheriker, Hadar

AU - Stern Bauer, Tal

AU - Oren, Yuval

AU - Nir, Shlomo

AU - Hayouka, Zvi

PY - 2020/9/25

Y1 - 2020/9/25

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Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Abstract

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