Abstract
The lytic mechanism expressed by murine macrophages in allogeneic mixed macrophage culture was investigated by electron microscopy. Cationized ferritin was used as an outer cellular surface marker in an attempt to elucidate the cell to cell relationship of killer and target cells. The findings obtained in this study suggest that killer and target cells are in close apposition (80 to 100 Å approximate distance) with no fusion or surface membranes. Phagocytosis of target cells was not observed. Possible explanations of the lytic mechanism in mixed macrophage cultures are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 44-52 |
| Number of pages | 9 |
| Journal | RES Journal of the Reticuloendothelial Society |
| Volume | 18 |
| Issue number | 1 |
| State | Published - 1975 |