Immune-modulating activities of glucans extracted from Pleurotus ostreatus and Pleurotus eryngii

Vaclav Vetvicka, Ofer Gover, Michal Karpovsky, Hilla Hayby, Ofer Danay, Nirit Ezov, Yitzhak Hadar, Betty Schwartz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


We compared the immune-modulating activity of glucans extracted from P. ostreatus and P. eryngii on phagocytosis of peripheral blood neutrophils, and superoxide release from HL-60 cells. The results suggest that the anti-inflammatory properties of these glucans are partially mediated through modulation of neutrophil effector functions (P. eryngii was more effective). Additionally, both glucans dose-dependently competed for the anti-Dectin-1 and anti-CR3 antibody binding. We then tested the putative anti-inflammatory effects of the extracted glucans in inflammatory bowel disease (IBD) using the dextran sulfate sodium (DSS)–induced model in mice. The clinical symptoms of IBD were efficiently relieved by the treatment with two different doses of the glucan from both fungi. Glucan fractions, from either P. ostreatus or P. eryngii, markedly prevented TNF-α mediated inflammation in the DSS–induced inflamed intestine. These results suggest that there are variations in glucan preparations from different fungi in their anti-inflammatory ability.

Original languageAmerican English
Pages (from-to)81-91
Number of pages11
JournalJournal of Functional Foods
StatePublished - Mar 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd


  • DSS-treated mice
  • Glucans
  • Inflammation
  • Inflammatory bowel disease
  • P. eryngii
  • P. ostreatus


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