TY - JOUR
T1 - Immune responses to weakly immunogenic murine-leukemia-virus-induced tumors. VII. Kinetic studies on various parameters of effects induced with suppressor cells
AU - Deutsch, O.
AU - Devens, B.
AU - Naor, D.
PY - 1980
Y1 - 1980
N2 - YAC, a Moloney-virus-induced tumor of A mice, caused an inhibition of specific immunologic responses in A and C57BL/6 mice, which was mediated by suppressor cells. In contrast, YAC-1, the in vitro-carried tumor derived from cultivated YAC cells, stimulated the appearance of antitumor reactive cells in A mice. Splenocytes from YAC-1-injected mice generated anti-YAC cytotoxic cells after 6 days of culture. The suppressor cells from YAC-injected mice efficiently inhibited the cytotoxic responses of the cultivated reactive cells (YAC-1-primed cells) when added at the start of the culture, but not when added at later times. Suppressor cells appeared in A mice 3 days after injection of YAC cells and persisted in the animals for at least 50 days. YAC-1-primed cells, derived from A mice 1, 3, 9 and 20 days after injection of YAC-1 cells, were sensitive to the suppressor cells.
AB - YAC, a Moloney-virus-induced tumor of A mice, caused an inhibition of specific immunologic responses in A and C57BL/6 mice, which was mediated by suppressor cells. In contrast, YAC-1, the in vitro-carried tumor derived from cultivated YAC cells, stimulated the appearance of antitumor reactive cells in A mice. Splenocytes from YAC-1-injected mice generated anti-YAC cytotoxic cells after 6 days of culture. The suppressor cells from YAC-injected mice efficiently inhibited the cytotoxic responses of the cultivated reactive cells (YAC-1-primed cells) when added at the start of the culture, but not when added at later times. Suppressor cells appeared in A mice 3 days after injection of YAC cells and persisted in the animals for at least 50 days. YAC-1-primed cells, derived from A mice 1, 3, 9 and 20 days after injection of YAC-1 cells, were sensitive to the suppressor cells.
UR - http://www.scopus.com/inward/record.url?scp=0018879808&partnerID=8YFLogxK
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 6447122
AN - SCOPUS:0018879808
SN - 0021-2180
VL - 16
SP - 530
EP - 537
JO - Israel Journal of Medical Sciences
JF - Israel Journal of Medical Sciences
IS - 7
ER -