Immunity and adhesion-GPCRs

Simon Yona, Hsi Hsien Lin, Martin Stacey*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations


Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily members are predominantly expressed by leukocytes and involved in coordinating both the innate and acquired immune responses. Here we highlight some immunological insights in relation to EGF-TM7 proteins and other members of the adhesion-GPCR family.

Original languageAmerican English
Title of host publicationAdhesion-GPCRs
Subtitle of host publicationStructure to Function
EditorsSimon Yona, Martin Stacey
Number of pages7
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


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