Abstract
The preparation of an inactivated oil adjuvant vaccine of Newcastle Disease virus (NDV) using β propiolactone (BPL) is described. The method used also caused inactivation of avian sarcoma viruses. Intramuscular or subcutaneous injections in 4 week old chickens evoked high levels of hemagglutination inhibiting (HI) antibodies in the serum which persisted over long periods. It also conferred immunity against challenge with 2 x 105 ELD50 of a virulent strain of NDV administered intramuscularly or by contact.
Original language | English |
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Pages (from-to) | 598-604 |
Number of pages | 7 |
Journal | Avian Diseases |
Volume | 17 |
Issue number | 3 |
DOIs | |
State | Published - 1973 |