Immunization of chickens with an inactivated oil adjuvant Newcastle disease virus vaccine

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Abstract

The preparation of an inactivated oil adjuvant vaccine of Newcastle Disease virus (NDV) using β propiolactone (BPL) is described. The method used also caused inactivation of avian sarcoma viruses. Intramuscular or subcutaneous injections in 4 week old chickens evoked high levels of hemagglutination inhibiting (HI) antibodies in the serum which persisted over long periods. It also conferred immunity against challenge with 2 x 105 ELD50 of a virulent strain of NDV administered intramuscularly or by contact.

Original languageEnglish
Pages (from-to)598-604
Number of pages7
JournalAvian Diseases
Volume17
Issue number3
DOIs
StatePublished - 1973

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