Immunization of chickens with an inactivated oil adjuvant Newcastle disease virus vaccine

R. Levy; Z. Zakay Rones

doi:10.2307/1589160

Immunization of chickens with an inactivated oil adjuvant Newcastle disease virus vaccine

R. Levy
, Z. Zakay Rones

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The preparation of an inactivated oil adjuvant vaccine of Newcastle Disease virus (NDV) using β propiolactone (BPL) is described. The method used also caused inactivation of avian sarcoma viruses. Intramuscular or subcutaneous injections in 4 week old chickens evoked high levels of hemagglutination inhibiting (HI) antibodies in the serum which persisted over long periods. It also conferred immunity against challenge with 2 x 10⁵ ELD₅₀ of a virulent strain of NDV administered intramuscularly or by contact.

Original language	English
Pages (from-to)	598-604
Number of pages	7
Journal	Avian Diseases
Volume	17
Issue number	3
DOIs	https://doi.org/10.2307/1589160
State	Published - 1973

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10.2307/1589160

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abstract = "The preparation of an inactivated oil adjuvant vaccine of Newcastle Disease virus (NDV) using β propiolactone (BPL) is described. The method used also caused inactivation of avian sarcoma viruses. Intramuscular or subcutaneous injections in 4 week old chickens evoked high levels of hemagglutination inhibiting (HI) antibodies in the serum which persisted over long periods. It also conferred immunity against challenge with 2 x 105 ELD50 of a virulent strain of NDV administered intramuscularly or by contact.",

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Immunization of chickens with an inactivated oil adjuvant Newcastle disease virus vaccine

Abstract

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