Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitis

Tamir Ben-Hur*, Anna Itzik, Ohr Barak, Yael Asher, Yechiel Becker, Raz Yirmiya, Joseph Weidenfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We examined whether immunization with the nonpathogenic strain R-15 of herpes simplex virus-1 (HSV-1) may prevent the clinical and neuroendocrine changes induced by the pathogenic HSV-1 strain Syn17+. Inoculation of strain Syn17+ to control rats induced fever, marked motor hyperactivity and aggressive behavior, and increased serum ACTH, corticosterone (CS) and brain prostaglandin-E2 production. Mortality was 100%. Immunization with strain R-15 prior to challenge with Syn17+ induced the production of neutralizing antibodies to HSV-1 Syn17+, and abolished the above clinical and neuroendocrine changes. Mortality was completely prevented. These results indicate that immunization with HSV-1 strain R-15 protects rats from lethal HSV-1 encephalitis and prevents its clinical and neurochemical manifestations.

Original languageAmerican English
Pages (from-to)5-10
Number of pages6
JournalJournal of Neuroimmunology
Volume152
Issue number1-2
DOIs
StatePublished - Jul 2004

Bibliographical note

Funding Information:
This study was supported in part by the Hilda Katz Blaustein Fund for research in Neurology.

Keywords

  • Adrenocortical axis
  • Vaccine
  • Viral encephalitis

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