Immunogenetic control of metastasis formation by a methylcholanthrene-induced tumor (T10) in mice: differential expression of H-2 gene products

S Katzav; P De Baetselier; E Gorelik; M Feldman; S Segal

Immunogenetic control of metastasis formation by a methylcholanthrene-induced tumor (T10) in mice: differential expression of H-2 gene products

S Katzav, P De Baetselier, E Gorelik, M Feldman, S Segal

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In view of the determinative role of the MHC system in controlling and restricting the function of immune effector cells against modified self components, one could assume that modulation of the expression of MHC-encoded antigens on tumor cells creates different communications with the host's immune system and thus influences the interclonal relationships within a tumor population, provided the antitumor response is H-2 restricted. In this study, we report differences in the membrane expression of H-2 parental haplotypes between a local methylcholanthrene-induced tumor (T10) and its descendant pulmonary metastases.

Original language	English
Pages (from-to)	742-6
Number of pages	5
Journal	Transplantation Proceedings
Volume	13
Issue number	1 Pt 2
State	Published - Mar 1981
Externally published	Yes

Keywords

Animals
Antigens, Neoplasm/immunology
Epitopes
Fluorescent Antibody Technique
H-2 Antigens/immunology
Male
Mice
Mice, Inbred C3H/immunology
Mice, Inbred C57BL/immunology
Sarcoma, Experimental/immunology

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title = "Immunogenetic control of metastasis formation by a methylcholanthrene-induced tumor (T10) in mice: differential expression of H-2 gene products",

abstract = "In view of the determinative role of the MHC system in controlling and restricting the function of immune effector cells against modified self components, one could assume that modulation of the expression of MHC-encoded antigens on tumor cells creates different communications with the host's immune system and thus influences the interclonal relationships within a tumor population, provided the antitumor response is H-2 restricted. In this study, we report differences in the membrane expression of H-2 parental haplotypes between a local methylcholanthrene-induced tumor (T10) and its descendant pulmonary metastases.",

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author = "S Katzav and {De Baetselier}, P and E Gorelik and M Feldman and S Segal",

year = "1981",

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language = "אנגלית",

volume = "13",

pages = "742--6",

journal = "Transplantation Proceedings",

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T1 - Immunogenetic control of metastasis formation by a methylcholanthrene-induced tumor (T10) in mice

T2 - differential expression of H-2 gene products

AU - Katzav, S

AU - De Baetselier, P

AU - Gorelik, E

AU - Feldman, M

AU - Segal, S

PY - 1981/3

Y1 - 1981/3

N2 - In view of the determinative role of the MHC system in controlling and restricting the function of immune effector cells against modified self components, one could assume that modulation of the expression of MHC-encoded antigens on tumor cells creates different communications with the host's immune system and thus influences the interclonal relationships within a tumor population, provided the antitumor response is H-2 restricted. In this study, we report differences in the membrane expression of H-2 parental haplotypes between a local methylcholanthrene-induced tumor (T10) and its descendant pulmonary metastases.

AB - In view of the determinative role of the MHC system in controlling and restricting the function of immune effector cells against modified self components, one could assume that modulation of the expression of MHC-encoded antigens on tumor cells creates different communications with the host's immune system and thus influences the interclonal relationships within a tumor population, provided the antitumor response is H-2 restricted. In this study, we report differences in the membrane expression of H-2 parental haplotypes between a local methylcholanthrene-induced tumor (T10) and its descendant pulmonary metastases.

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KW - Antigens, Neoplasm/immunology

KW - Epitopes

KW - Fluorescent Antibody Technique

KW - H-2 Antigens/immunology

KW - Male

KW - Mice

KW - Mice, Inbred C3H/immunology

KW - Mice, Inbred C57BL/immunology

KW - Sarcoma, Experimental/immunology

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SN - 0041-1345

VL - 13

SP - 742

EP - 746

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 1 Pt 2

ER -

Immunogenetic control of metastasis formation by a methylcholanthrene-induced tumor (T10) in mice: differential expression of H-2 gene products

Abstract

Keywords

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