TY - JOUR
T1 - Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G
AU - Jefferis, Royston
AU - Nik Jaafar, M. Iskandar
AU - Steinitz, Michael
PY - 1984
Y1 - 1984
N2 - A monoclonal human rheumatoid factor (RF-AN) reactive with human Fcγ is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having Cγ2 or Cγ3 domain deletions or IgG3m (5) or IgG3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.
AB - A monoclonal human rheumatoid factor (RF-AN) reactive with human Fcγ is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having Cγ2 or Cγ3 domain deletions or IgG3m (5) or IgG3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.
KW - IgG isotopes
KW - monoclonal antibodies
KW - monoclonal rheumatoid factor
UR - http://www.scopus.com/inward/record.url?scp=0021059401&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(84)90042-7
DO - 10.1016/0165-2478(84)90042-7
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C2 - 6200430
AN - SCOPUS:0021059401
SN - 0165-2478
VL - 7
SP - 191
EP - 194
JO - Immunology Letters
JF - Immunology Letters
IS - 4
ER -