Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G

Royston Jefferis; M. Iskandar Nik Jaafar; Michael Steinitz

doi:10.1016/0165-2478(84)90042-7

Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G

Royston Jefferis^*
, M. Iskandar Nik Jaafar
, Michael Steinitz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A monoclonal human rheumatoid factor (RF-AN) reactive with human Fcγ is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having Cγ2 or Cγ3 domain deletions or IgG3m (5) or IgG3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Immunology Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/0165-2478(84)90042-7
State	Published - 1984
Externally published	Yes

Keywords

IgG isotopes
monoclonal antibodies
monoclonal rheumatoid factor

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10.1016/0165-2478(84)90042-7

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title = "Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G",

abstract = "A monoclonal human rheumatoid factor (RF-AN) reactive with human Fcγ is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having Cγ2 or Cγ3 domain deletions or IgG3m (5) or IgG3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.",

keywords = "IgG isotopes, monoclonal antibodies, monoclonal rheumatoid factor",

author = "Royston Jefferis and \{Nik Jaafar\}, \{M. Iskandar\} and Michael Steinitz",

year = "1984",

doi = "10.1016/0165-2478(84)90042-7",

language = "אנגלית",

volume = "7",

pages = "191--194",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

number = "4",

}

Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G. / Jefferis, Royston; Nik Jaafar, M. Iskandar; Steinitz, Michael.
In: Immunology Letters, Vol. 7, No. 4, 1984, p. 191-194.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G

AU - Jefferis, Royston

AU - Nik Jaafar, M. Iskandar

AU - Steinitz, Michael

PY - 1984

Y1 - 1984

N2 - A monoclonal human rheumatoid factor (RF-AN) reactive with human Fcγ is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having Cγ2 or Cγ3 domain deletions or IgG3m (5) or IgG3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.

AB - A monoclonal human rheumatoid factor (RF-AN) reactive with human Fcγ is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having Cγ2 or Cγ3 domain deletions or IgG3m (5) or IgG3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.

KW - IgG isotopes

KW - monoclonal antibodies

KW - monoclonal rheumatoid factor

UR - https://www.scopus.com/pages/publications/0021059401

U2 - 10.1016/0165-2478(84)90042-7

DO - 10.1016/0165-2478(84)90042-7

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C2 - 6200430

AN - SCOPUS:0021059401

SN - 0165-2478

VL - 7

SP - 191

EP - 194

JO - Immunology Letters

JF - Immunology Letters

IS - 4

ER -

Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G

Abstract

Keywords

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