TY - JOUR
T1 - Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40
AU - Beraud, Evelyne
AU - Lorberboum-Galski, Haya
AU - Chan, Chi Chao
AU - FitzGerald, David
AU - Pastan, Ira
AU - Nussenblatt, Robert B.
PY - 1991/4/1
Y1 - 1991/4/1
N2 - We examined the action of a chimeric protein, IL-2-PE40, on the development of a T cell-mediated disease of the central nervous system with numerous similarities to multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). EAE is caused by IL-2 receptor-bearing T cells specific for myelin basic protein (BP). We report here that the treatment of Lewis rats with IL-2-PE40 delayed and shortened the course of EAE induced by BP in adjuvant and dramatically prevented EAE mediated by anti-myelin basic protein T line cells. The absence of paralytic signs, the absence of cell infiltration in the central nervous system, and the abatement of cellular immunity to myelin basic protein in the treated rats are direct consequences of the specific mechanism of action of IL-2-PE40. Our data support the notion that IL-2-PE40 may be efficient as an immunosuppressive agent for those disorders in which activated T cells play a crucial role.
AB - We examined the action of a chimeric protein, IL-2-PE40, on the development of a T cell-mediated disease of the central nervous system with numerous similarities to multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). EAE is caused by IL-2 receptor-bearing T cells specific for myelin basic protein (BP). We report here that the treatment of Lewis rats with IL-2-PE40 delayed and shortened the course of EAE induced by BP in adjuvant and dramatically prevented EAE mediated by anti-myelin basic protein T line cells. The absence of paralytic signs, the absence of cell infiltration in the central nervous system, and the abatement of cellular immunity to myelin basic protein in the treated rats are direct consequences of the specific mechanism of action of IL-2-PE40. Our data support the notion that IL-2-PE40 may be efficient as an immunosuppressive agent for those disorders in which activated T cells play a crucial role.
UR - http://www.scopus.com/inward/record.url?scp=0026027966&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(91)90112-O
DO - 10.1016/0008-8749(91)90112-O
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 1707763
AN - SCOPUS:0026027966
SN - 0008-8749
VL - 133
SP - 379
EP - 389
JO - Cellular Immunology
JF - Cellular Immunology
IS - 2
ER -