Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40

Evelyne Beraud*, Haya Lorberboum-Galski, Chi Chao Chan, David FitzGerald, Ira Pastan, Robert B. Nussenblatt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We examined the action of a chimeric protein, IL-2-PE40, on the development of a T cell-mediated disease of the central nervous system with numerous similarities to multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). EAE is caused by IL-2 receptor-bearing T cells specific for myelin basic protein (BP). We report here that the treatment of Lewis rats with IL-2-PE40 delayed and shortened the course of EAE induced by BP in adjuvant and dramatically prevented EAE mediated by anti-myelin basic protein T line cells. The absence of paralytic signs, the absence of cell infiltration in the central nervous system, and the abatement of cellular immunity to myelin basic protein in the treated rats are direct consequences of the specific mechanism of action of IL-2-PE40. Our data support the notion that IL-2-PE40 may be efficient as an immunosuppressive agent for those disorders in which activated T cells play a crucial role.

Original languageAmerican English
Pages (from-to)379-389
Number of pages11
JournalCellular Immunology
Issue number2
StatePublished - 1 Apr 1991
Externally publishedYes


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