TY - JOUR
T1 - Immunotherapy in clinical canine leishmaniosis
T2 - a comparative update
AU - Baxarias, M.
AU - Martínez-Orellana, Pamela
AU - Baneth, Gad
AU - Solano-Gallego, Laia
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/8
Y1 - 2019/8
N2 - Leishmaniosis due to Leishmania infantum is a complex infection that can affect both humans and dogs, and present a wide range of clinical signs and clinicopathological abnormalities. The conventional treatment of this disease is challenging due to the fact that complete parasitological cure commonly does not occur. Furthermore, treatment of the disease with the conventionally used drugs has several shortcomings. These include the need for long-term treatment, side effects and the formation of drug resistance. Moreover, it is important to highlight that the host immune responses play a crucial role in the outcome of this infection. For this reason, the use of immunotherapy in clinical leishmaniosis to improve the result of treatment with the conventional anti-leishmanial drugs by enhancing the immune response is imperative. The aim of this review is to provide a comparative overview of the wide range of immunotherapeutical approaches and strategies for the treatment of L. infantum infection in animals focusing on dogs.
AB - Leishmaniosis due to Leishmania infantum is a complex infection that can affect both humans and dogs, and present a wide range of clinical signs and clinicopathological abnormalities. The conventional treatment of this disease is challenging due to the fact that complete parasitological cure commonly does not occur. Furthermore, treatment of the disease with the conventionally used drugs has several shortcomings. These include the need for long-term treatment, side effects and the formation of drug resistance. Moreover, it is important to highlight that the host immune responses play a crucial role in the outcome of this infection. For this reason, the use of immunotherapy in clinical leishmaniosis to improve the result of treatment with the conventional anti-leishmanial drugs by enhancing the immune response is imperative. The aim of this review is to provide a comparative overview of the wide range of immunotherapeutical approaches and strategies for the treatment of L. infantum infection in animals focusing on dogs.
KW - Dog
KW - Drug
KW - Human
KW - Immunomodulation
KW - Leishmania infantum
KW - Mice
UR - http://www.scopus.com/inward/record.url?scp=85068261789&partnerID=8YFLogxK
U2 - 10.1016/j.rvsc.2019.06.009
DO - 10.1016/j.rvsc.2019.06.009
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C2 - 31280121
AN - SCOPUS:85068261789
SN - 0034-5288
VL - 125
SP - 218
EP - 226
JO - Research in Veterinary Science
JF - Research in Veterinary Science
ER -