Impaired β-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

Keyphrases

• Cell Function 100%
• Chronic Exposure 100%
• High Glucose 100%
• Human Pancreatic Islets 100%
• Islet 50%
• Transcription Factor 33%
• Insulin 33%
• Proinsulin 33%
• Promoter Elements 16%
• Insulin Release 16%
• MRNA Level 16%
• Deleterious Effects 16%
• Type 2 Diabetes Mellitus (T2DM) 16%
• Type 2 Diabetic Patients 16%
• Glucose-stimulated Insulin Secretion 16%
• Human Islets 16%
• Islet Culture 16%
• Chronic Hyperglycemia 16%
• In Vivo Exposure 16%
• Binding Activity 16%
• Insulin mRNA 16%
• Insulin Content 16%
• Insulin Secretion 16%
• Insulin Sensitizers 16%
• Functional Level 16%
• Like Peptide 16%
• Human Insulin Promoter 16%
• Insulin Promoter 16%
• Glucose Sensitivity 16%
• Insulin Production 16%
• Pancreatic and Duodenal Homeobox 1 16%
• Promoter Transcriptional Activity 16%

Biochemistry, Genetics and Molecular Biology

• Cell Function 100%
• Transcription Factors 66%
• Insulin Release 66%
• Proinsulin 66%
• Promoter Region 33%
• Secretion (Process) 33%
• Enhancer Region 33%
• Binding Affinity 33%
• Pribnow Box 33%
• Homeobox 33%
• Glucose Level 33%
• Hyperglycemia 33%
• Messenger RNA 33%
• Fibrinogen 33%

Immunology and Microbiology

• Cell Function 100%
• Transcription Factors 66%
• Insulin Release 66%
• Promoter Region 66%
• Secretion (Process) 33%
• Enhancer Region 33%
• Homeobox 33%
• Binding Affinity 33%
• Glucose Level 33%
• Fibrinogen 33%