Abstract
Bactericidal activity of normal and irradiated murine macrophages was analyzed by assaying the incorporation of 3H-thymidine by phagocytized Staphylococcus albus autoradiographically. Following sublethal or lethal X-irradiation, murine macrophages lost some of their bactericidal capacity. While 16 per cent of the intracellular Staphylococci were labelled in normal macrophages, 47 and 52 per cent of the engulfed bacteria were labelled in 550r and 800r irradiated macrophages, respectively. This impairment of bactericidal function might be responsible for post irradiation infections and bacteremia observed in X-irradiated animals or humans.
| Original language | English |
|---|---|
| Pages (from-to) | 611-614 |
| Number of pages | 4 |
| Journal | Immunochemistry |
| Volume | 12 |
| Issue number | 6-7 |
| DOIs | |
| State | Published - Jul 1975 |