Improvement of dry mouth following intraductal irrigation of salivary glands

Doron J. Aframian*, Sagit Baaton, Sigal Mazor, Chen Nadler, Naama Keshet, Yaron Haviv, Yehuda Zadik, Rinat Schwimmer-Noy, Boaz Shay, Galit Almoznino

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objectives: To assess the effect of major salivary gland intraductal irrigations (IGs) to relieve mouth dryness. Methods: We retrospectively analyzed the records of patients with mouth dryness who underwent major salivary gland IG during 2013–2015. Records included demographics, medical background, dry mouth etiologies and symptomatology, and results of sialometry and sialo-cone-beam computerized tomography. Subjective improvement following the IG procedure (yes/no) and sustained subjective improvement (mouth dryness relief for ≥1 month) were recorded. Objective improvement was assessed by comparing the mean unstimulated (USF) and stimulated (SSF) whole salivary flow (WSF) rate before and after the IG. Results: Seventy-four patients were included [mean age: 59.08 ± 12.46 years]. Improvement was detected in the USF (p =.027), but not in the SSF (p =.878). Fifty-five (84.6%) noted subjective improvement, while 10 (15.4%) did not. Subjective improvement was positively associated with the USF following IG (p =.037), with salivary gland swelling episodes (p =.033), and with difficulties in swallowing dry foods (p =.014). Of those with subjective improvement, 45 (81.8%) reported sustained improvement, which was positively associated with lack of a gritty eye sensation (p =.042) and abnormal sialo-CBCT findings (p =.001). Conclusions: Major salivary gland IG is a simple and safe procedure that may relieve dry mouth for a relatively extended duration. Further studies are needed to confirm these preliminary findings and assess their underlying mechanisms.

Original languageAmerican English
Pages (from-to)1735-1743
Number of pages9
JournalOral Diseases
Issue number7
StatePublished - 1 Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved


  • dry mouth
  • intraductal salivary irrigation
  • medication-induced salivary gland dysfunction
  • saliva
  • salivary flow
  • salivary glands


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