In Situ Potentiostatic Deposition of Calcium Phosphate with Gentamicin-Loaded Chitosan Nanoparticles on Titanium Alloy Surfaces

Midhun B. Thomas; Noah Metoki; Daniel Mandler; Noam Eliaz

doi:10.1016/j.electacta.2016.10.186

In Situ Potentiostatic Deposition of Calcium Phosphate with Gentamicin-Loaded Chitosan Nanoparticles on Titanium Alloy Surfaces

Midhun B. Thomas, Noah Metoki, Daniel Mandler, Noam Eliaz^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Bone implants must be biocompatible and are usually built to promote osseointegration, e.g. by application of plasma spray calcium phosphate (CaP) coating. The risk of infection and biofilm formation on implant surfaces is a well-known problem. The combination of electrochemically deposited CaP coating with antibiotics may offer significant benefits. Here, we demonstrate an innovative in situ electrodeposition of gentamicin encapsulated in chitosan nanoparticles along with CaP. The deposition of the coating was observed and studied at several temperatures. A high drug loading into the coating and a controlled release of the drug over two days were demonstrated.

Original language	English
Pages (from-to)	355-360
Number of pages	6
Journal	Electrochimica Acta
Volume	222
DOIs	https://doi.org/10.1016/j.electacta.2016.10.186
State	Published - 20 Dec 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

calcium phosphate
drug release
electrodeposition
gentamicin antibiotics
in-situ deposition

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10.1016/j.electacta.2016.10.186

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abstract = "Bone implants must be biocompatible and are usually built to promote osseointegration, e.g. by application of plasma spray calcium phosphate (CaP) coating. The risk of infection and biofilm formation on implant surfaces is a well-known problem. The combination of electrochemically deposited CaP coating with antibiotics may offer significant benefits. Here, we demonstrate an innovative in situ electrodeposition of gentamicin encapsulated in chitosan nanoparticles along with CaP. The deposition of the coating was observed and studied at several temperatures. A high drug loading into the coating and a controlled release of the drug over two days were demonstrated.",

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AU - Mandler, Daniel

AU - Eliaz, Noam

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AB - Bone implants must be biocompatible and are usually built to promote osseointegration, e.g. by application of plasma spray calcium phosphate (CaP) coating. The risk of infection and biofilm formation on implant surfaces is a well-known problem. The combination of electrochemically deposited CaP coating with antibiotics may offer significant benefits. Here, we demonstrate an innovative in situ electrodeposition of gentamicin encapsulated in chitosan nanoparticles along with CaP. The deposition of the coating was observed and studied at several temperatures. A high drug loading into the coating and a controlled release of the drug over two days were demonstrated.

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KW - drug release

KW - electrodeposition

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KW - in-situ deposition

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In Situ Potentiostatic Deposition of Calcium Phosphate with Gentamicin-Loaded Chitosan Nanoparticles on Titanium Alloy Surfaces

Abstract

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