In Situ Potentiostatic Deposition of Calcium Phosphate with Gentamicin-Loaded Chitosan Nanoparticles on Titanium Alloy Surfaces

Midhun B. Thomas, Noah Metoki, Daniel Mandler, Noam Eliaz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Bone implants must be biocompatible and are usually built to promote osseointegration, e.g. by application of plasma spray calcium phosphate (CaP) coating. The risk of infection and biofilm formation on implant surfaces is a well-known problem. The combination of electrochemically deposited CaP coating with antibiotics may offer significant benefits. Here, we demonstrate an innovative in situ electrodeposition of gentamicin encapsulated in chitosan nanoparticles along with CaP. The deposition of the coating was observed and studied at several temperatures. A high drug loading into the coating and a controlled release of the drug over two days were demonstrated.

Original languageAmerican English
Pages (from-to)355-360
Number of pages6
JournalElectrochimica Acta
Volume222
DOIs
StatePublished - 20 Dec 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

  • calcium phosphate
  • drug release
  • electrodeposition
  • gentamicin antibiotics
  • in-situ deposition

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