TY - JOUR
T1 - In vitro and in silico interaction studies with red wine polyphenols against different proteins from human serum†
AU - Shafreen, Raja Mohamed Beema
AU - Lakshmi, Selvaraj Alagu
AU - Pandian, Shunmugiah Karutha
AU - Kim, Young Mo
AU - Deutsch, Joseph
AU - Katrich, Elena
AU - Gorinstein, Shela
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Previous reports have shown that consumption of wine has several health benefits; how-ever, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candi-dates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.
AB - Previous reports have shown that consumption of wine has several health benefits; how-ever, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candi-dates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.
KW - Albumin
KW - Antioxidant activities
KW - Beverages
KW - Binding properties
KW - Fibrinogen
KW - Health properties
KW - Resveratrol
KW - Rutin
KW - Tannic acid
UR - http://www.scopus.com/inward/record.url?scp=85119590376&partnerID=8YFLogxK
U2 - 10.3390/molecules26216686
DO - 10.3390/molecules26216686
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C2 - 34771095
AN - SCOPUS:85119590376
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 21
M1 - 6686
ER -