In vitro and preclinical characterisation of compressed, macro-porous and collagen coated poly-ϵ-caprolactone electro-spun scaffolds

Kieran P. Fuller, Diana Gaspar, Luis M. Delgado, Oded Shoseyov, Dimitrios I. Zeugolis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Low in macro-porosity electro-spun scaffolds are often associated with foreign body response, whilst macro-porous electro-spun scaffolds have low mechanical integrity. Herein, compressed, macro-porous and collagen (bovine Achilles tendon and human recombinant) coated electro-spun poly-ϵ-caprolactone scaffolds were developed and their biomechanical, in vitro and in vivo properties were assessed. Collagen coating, independently of the source, did not significantly affect the biomechanical properties of the scaffolds. Although no significant difference in cell viability was observed between the groups, collagen coated scaffolds induced significantly higher DNA concentration. In vivo, no signs of adverse tissue effect were observed in any of the groups and all groups appeared to equally integrate into the subcutaneous tissue. It is evidenced that macro-porous poly-ϵ-caprolactone electro-spun meshes with adequate mechanical properties and acceptable host response can be developed for biomedical applications.

Original languageAmerican English
Article number055007
JournalBiomedical Materials (Bristol)
Volume14
Issue number5
DOIs
StatePublished - 19 Jul 2019

Bibliographical note

Publisher Copyright:
© 2019 IOP Publishing Ltd.

Keywords

  • bovine collagen
  • electro-spun scaffolds
  • human recombinant collagen
  • subcutaneous implantation

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