Abstract
Objective: To report the responses to IVF surrogacy attempts in a female with a heretofore never described combination of Mayer-Rokitansky-Kuster-Hauser (MRHK) syndrome and triple X karyotype. Design: Case report. Setting: Reproductive unit of a university-affiliated medical center. Patient(s): A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype. Intervention(s): Five cycles of IVF surrogacy. Main Outcome Measure(s): Recovery of oocytes after controlled ovarian stimulation. Result(s): A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation. Conclusion(s): An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.
| Original language | English |
|---|---|
| Pages (from-to) | 1788.e11-1788.e13 |
| Journal | Fertility and Sterility |
| Volume | 95 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 2011 |
| Externally published | Yes |
Keywords
- MRKH syndrome
- low ovarian response
- primary amenorrhea
- surrogacy
- surrogate IVF
- triple X karyotype
- vaginal agenesis