In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy

Hyla Allouche-Arnon; Ayelet Gamliel; Jacob Sosna; J. Moshe Gomori; Rachel Katz-Brull

doi:10.1039/c3cc42542h

In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy

Hyla Allouche-Arnon, Ayelet Gamliel, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and¹³C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.

Original language	English
Pages (from-to)	7076-7078
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	63
DOIs	https://doi.org/10.1039/c3cc42542h
State	Published - 11 Jul 2013
Externally published	Yes

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title = "In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy",

abstract = "Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and13C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.",

author = "Hyla Allouche-Arnon and Ayelet Gamliel and Jacob Sosna and {Moshe Gomori}, J. and Rachel Katz-Brull",

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AU - Allouche-Arnon, Hyla

AU - Gamliel, Ayelet

AU - Sosna, Jacob

AU - Moshe Gomori, J.

AU - Katz-Brull, Rachel

PY - 2013/7/11

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N2 - Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and13C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.

AB - Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and13C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.

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In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy

Abstract

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