In vivo and in vitro toxicity of newly synthesized Monofunctional sulfur mustard derivatives

Uri Wormser; Bernard S. Green; Rina Arad-Yellin; Berta Brodsky; Igor Shatz; Abraham Nyska

doi:10.1016/0300-483X(95)03288-Q

In vivo and in vitro toxicity of newly synthesized Monofunctional sulfur mustard derivatives

Uri Wormser^*, Bernard S. Green, Rina Arad-Yellin, Berta Brodsky, Igor Shatz, Abraham Nyska

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compounds (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative effect. CDCS exhibited similar pathological effects. Dimethylsulfoxide (DMSO) exacerbated CBCS toxicity. Regeneration and healing were prominent six days after application. Concentration-related effects were found in in vitro systems, using human SH-SY5Y neuroblastoma cells for acute toxicity and Y79 retinoblastoma cells for colony forming assay. CBCS or derivatives may serve as model compounds for investigating the mechanism of action of alkylating agents.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	Toxicology
Volume	108
Issue number	1-2
DOIs	https://doi.org/10.1016/0300-483X(95)03288-Q
State	Published - 15 Apr 1996

Keywords

10-Carboxydecyl 2-chloroethyl sulfide
4-Carboxybutyl 2-chloroethyl sulfide
Monofunctional mustard
Sulfur mustard derivatives
Vesicant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0300-483X(95)03288-Q

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title = "In vivo and in vitro toxicity of newly synthesized Monofunctional sulfur mustard derivatives",

abstract = "The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compounds (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative effect. CDCS exhibited similar pathological effects. Dimethylsulfoxide (DMSO) exacerbated CBCS toxicity. Regeneration and healing were prominent six days after application. Concentration-related effects were found in in vitro systems, using human SH-SY5Y neuroblastoma cells for acute toxicity and Y79 retinoblastoma cells for colony forming assay. CBCS or derivatives may serve as model compounds for investigating the mechanism of action of alkylating agents.",

keywords = "10-Carboxydecyl 2-chloroethyl sulfide, 4-Carboxybutyl 2-chloroethyl sulfide, Monofunctional mustard, Sulfur mustard derivatives, Vesicant",

author = "Uri Wormser and Green, {Bernard S.} and Rina Arad-Yellin and Berta Brodsky and Igor Shatz and Abraham Nyska",

year = "1996",

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doi = "10.1016/0300-483X(95)03288-Q",

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AU - Wormser, Uri

AU - Green, Bernard S.

AU - Arad-Yellin, Rina

AU - Brodsky, Berta

AU - Shatz, Igor

AU - Nyska, Abraham

PY - 1996/4/15

Y1 - 1996/4/15

N2 - The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compounds (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative effect. CDCS exhibited similar pathological effects. Dimethylsulfoxide (DMSO) exacerbated CBCS toxicity. Regeneration and healing were prominent six days after application. Concentration-related effects were found in in vitro systems, using human SH-SY5Y neuroblastoma cells for acute toxicity and Y79 retinoblastoma cells for colony forming assay. CBCS or derivatives may serve as model compounds for investigating the mechanism of action of alkylating agents.

AB - The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compounds (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative effect. CDCS exhibited similar pathological effects. Dimethylsulfoxide (DMSO) exacerbated CBCS toxicity. Regeneration and healing were prominent six days after application. Concentration-related effects were found in in vitro systems, using human SH-SY5Y neuroblastoma cells for acute toxicity and Y79 retinoblastoma cells for colony forming assay. CBCS or derivatives may serve as model compounds for investigating the mechanism of action of alkylating agents.

KW - 10-Carboxydecyl 2-chloroethyl sulfide

KW - 4-Carboxybutyl 2-chloroethyl sulfide

KW - Monofunctional mustard

KW - Sulfur mustard derivatives

KW - Vesicant

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VL - 108

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EP - 128

JO - Toxicology

JF - Toxicology

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ER -

In vivo and in vitro toxicity of newly synthesized Monofunctional sulfur mustard derivatives

Abstract

Keywords

UN SDGs

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