In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

Keyphrases

• Clustered Regularly Interspaced Short Palindromic repeats/Cas9 100%
• Gene Function 100%
• Mammalian Brain 100%
• SpCas9 100%
• Multiple Genes 66%
• Eukaryotic Cells 33%
• Genetic Modification 33%
• Endonuclease 33%
• Genetic Studies 33%
• Genome Editing 33%
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 33%
• DNA Methyltransferase 3B (DNMT3B) 33%
• Reverse Genetics 33%
• DNA Methyltransferase 1 (DNMT1) 33%
• Streptococcus Pyogenes (S. pyogenes) 33%
• Deletion mutation 33%
• Guide RNA (gRNA) 33%
• Frameshift 33%
• Methyl-CpG-binding Protein 2 (MeCP2) 33%
• Biochemical Genetics 33%
• Adeno-associated Viral Vector 33%
• Insertion-deletion 33%
• Postmitotic Neurons 33%
• Adult Mouse Brain 33%
• Protein Depletion 33%
• Adeno-associated Viral 33%
• DNMT3A 33%

Biochemistry, Genetics and Molecular Biology

• Cas9 100%
• CRISPR 100%
• Gene Function 100%
• Genetics 66%
• Endonuclease 33%
• Genome Editing 33%
• Indel 33%
• Guide RNA 33%
• Mammal 33%
• Adeno Associated Virus Vector 33%
• Streptococcus pyogenes 33%

Neuroscience

• In Vivo 100%
• CRISPR 100%
• Gene Function 100%
• Indel Mutation 33%
• Adeno Associated Virus Vector 33%
• Guide RNA 33%
• Endonuclease 33%