Inactivation of vesicular stomatitis virus by photosensitization following incubation with a pyrene-fatty acid

S. Abou Rabia; E. Fibach; M. Kotler; S. Gatt

doi:10.1016/0014-5793(90)81222-A

Inactivation of vesicular stomatitis virus by photosensitization following incubation with a pyrene-fatty acid

S. Abou Rabia
, E. Fibach
, M. Kotler
, S. Gatt^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the virus, resulting in a drastic decrease of its infectivity. The virus inactivation was proportional to the concentration of the pyrene-fatty acid, the length of exposure of the virus to P12 and the irradiation dose.

Original language	English
Pages (from-to)	9-10
Number of pages	2
Journal	FEBS Letters
Volume	270
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(90)81222-A
State	Published - 17 Sep 1990

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abstract = "Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the virus, resulting in a drastic decrease of its infectivity. The virus inactivation was proportional to the concentration of the pyrene-fatty acid, the length of exposure of the virus to P12 and the irradiation dose.",

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AB - Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the virus, resulting in a drastic decrease of its infectivity. The virus inactivation was proportional to the concentration of the pyrene-fatty acid, the length of exposure of the virus to P12 and the irradiation dose.

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Inactivation of vesicular stomatitis virus by photosensitization following incubation with a pyrene-fatty acid

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