Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment

Vikram Khoshoo*, Michelle Zembo, Andrew King, Monica Dhar, Ram Reifen, Paul Pencharz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Ten exclusively gastrostomy-fed, neurologically impaired children (4.5- 14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein- or a whey-based formula for 48 h each and then crossed over to the other formula. One 24-h pH probe study each was performed while being fed casein- and whey-based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey-based formula (p < 0.05). Whey-based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3-12 months old) with documented gastroesophageal reflux using 24-h pH probe monitoring while consuming a casein-based formula. The formula was changed to a whey-based formula and the pH probe study repeated within 3- 5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey- formula was not significantly different from that with the casein-based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey-based formula in infants with gastroesophageal reflux cannot be made.

Original languageAmerican English
Pages (from-to)48-55
Number of pages8
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume22
Issue number1
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Casein
  • Cerebral palsy
  • Gastroesophageal reflux
  • Infants
  • Whey

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