Incorporating ecology into gene drive modelling

Jaehee Kim*, Keith D. Harris, Isabel K. Kim, Shahar Shemesh, Philipp W. Messer, Gili Greenbaum*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Gene drive technology, in which fast-spreading engineered drive alleles are introduced into wild populations, represents a promising new tool in the fight against vector-borne diseases, agricultural pests and invasive species. Due to the risks involved, gene drives have so far only been tested in laboratory settings while their population-level behaviour is mainly studied using mathematical and computational models. The spread of a gene drive is a rapid evolutionary process that occurs over timescales similar to many ecological processes. This can potentially generate strong eco-evolutionary feedback that could profoundly affect the dynamics and outcome of a gene drive release. We, therefore, argue for the importance of incorporating ecological features into gene drive models. We describe the key ecological features that could affect gene drive behaviour, such as population structure, life-history, environmental variation and mode of selection. We review previous gene drive modelling efforts and identify areas where further research is needed. As gene drive technology approaches the level of field experimentation, it is crucial to evaluate gene drive dynamics, potential outcomes, and risks realistically by including ecological processes.

Original languageAmerican English
Pages (from-to)S62-S80
JournalEcology Letters
Volume26
Issue numberS1
DOIs
StatePublished - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 John Wiley & Sons Ltd.

Keywords

  • eco-evolutionary dynamics
  • eco-evolutionary modelling
  • non-Mendelian inheritance
  • population genetics
  • population structure

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