Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats

J. Kapitulnik, J. P. Hardwick, J. D. Ostrow, C. C. Webster, S. S. Park, H. V. Gelboin

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31 Scopus citations

Abstract

Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16α-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalBiochemical Journal
Volume242
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

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