Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats

J. Kapitulnik; J. P. Hardwick; J. D. Ostrow; C. C. Webster; S. S. Park; H. V. Gelboin

doi:10.1042/bj2420297

Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats

J. Kapitulnik
, J. P. Hardwick
, J. D. Ostrow
, C. C. Webster
, S. S. Park
, H. V. Gelboin

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16α-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

Original language	English
Pages (from-to)	297-300
Number of pages	4
Journal	Biochemical Journal
Volume	242
Issue number	1
DOIs	https://doi.org/10.1042/bj2420297
State	Published - 1987
Externally published	Yes

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title = "Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats",

abstract = "Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16α-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.",

author = "J. Kapitulnik and Hardwick, \{J. P.\} and Ostrow, \{J. D.\} and Webster, \{C. C.\} and Park, \{S. S.\} and Gelboin, \{H. V.\}",

year = "1987",

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AU - Kapitulnik, J.

AU - Hardwick, J. P.

AU - Ostrow, J. D.

AU - Webster, C. C.

AU - Park, S. S.

AU - Gelboin, H. V.

PY - 1987

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AB - Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16α-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

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Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats

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