Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Adi F. Gazdar; Harold B. Stull; Lary J. Kilton; Uriel Bachrach

doi:10.1038/262696a0

Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Adi F. Gazdar^*, Harold B. Stull, Lary J. Kilton, Uriel Bachrach

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation^1,2, and the rate at which it proceeds ³ is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth^4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells ^3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones⁶. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change⁸.

Original language	English
Pages (from-to)	696-698
Number of pages	3
Journal	Nature
Volume	262
Issue number	5570
DOIs	https://doi.org/10.1038/262696a0
State	Published - 1976

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abstract = "POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.",

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AU - Gazdar, Adi F.

AU - Stull, Harold B.

AU - Kilton, Lary J.

AU - Bachrach, Uriel

PY - 1976

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AB - POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.

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Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Abstract

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