Increased response to peroxisomal proliferators in starved rats

Rachel Hertz; Jacob Bar-Tana

doi:10.1016/0005-2760(87)90283-9

Increased response to peroxisomal proliferators in starved rats

Rachel Hertz, Jacob Bar-Tana^*

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The induction of liver peroxisomal β-oxidation activities by bezafibrate or Wy 14,643 was 2-4-fold higher in starved rats than in fed animals. The increased response to peroxisomal proliferators in starved rats was independent of the mode of administration of the proliferator, given either orally or by intraperitoneal injection. Inhibitors of carnitine acyltransferase I could prevent the induction of peroxisomal activities in starved rats but not in fed animals. In contrast to fasted rats, the induction of liver peroxisomal activities in streptozotocin-diabetic rats was not susceptible to bezafibrate. The higher sensitivity to peroxisomal proliferators under conditions of starvation may allow for the detection of xenobiotic peroxisomal proliferators of low proliferative potency.

Original language	English
Pages (from-to)	57-61
Number of pages	5
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	917
Issue number	1
DOIs	https://doi.org/10.1016/0005-2760(87)90283-9
State	Published - 13 Jan 1987

Keywords

(Rat)
Beta-oxidation
Bezafibrate
Peroxisomal proliferation

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10.1016/0005-2760(87)90283-9

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abstract = "The induction of liver peroxisomal β-oxidation activities by bezafibrate or Wy 14,643 was 2-4-fold higher in starved rats than in fed animals. The increased response to peroxisomal proliferators in starved rats was independent of the mode of administration of the proliferator, given either orally or by intraperitoneal injection. Inhibitors of carnitine acyltransferase I could prevent the induction of peroxisomal activities in starved rats but not in fed animals. In contrast to fasted rats, the induction of liver peroxisomal activities in streptozotocin-diabetic rats was not susceptible to bezafibrate. The higher sensitivity to peroxisomal proliferators under conditions of starvation may allow for the detection of xenobiotic peroxisomal proliferators of low proliferative potency.",

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AU - Bar-Tana, Jacob

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AB - The induction of liver peroxisomal β-oxidation activities by bezafibrate or Wy 14,643 was 2-4-fold higher in starved rats than in fed animals. The increased response to peroxisomal proliferators in starved rats was independent of the mode of administration of the proliferator, given either orally or by intraperitoneal injection. Inhibitors of carnitine acyltransferase I could prevent the induction of peroxisomal activities in starved rats but not in fed animals. In contrast to fasted rats, the induction of liver peroxisomal activities in streptozotocin-diabetic rats was not susceptible to bezafibrate. The higher sensitivity to peroxisomal proliferators under conditions of starvation may allow for the detection of xenobiotic peroxisomal proliferators of low proliferative potency.

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Increased response to peroxisomal proliferators in starved rats

Abstract

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